Professor Ciclitira undertakes research into coeliac and inflammatory bowel disease. Investigation of coeliac disease involves studying (i) Identification of the toxic fractions in cereals, (ii) developing assays to quantify coeliac toxic fraction in foods for individuals with coeliac disease (iii) studying the disease mechanisms (iv) developing novel variants cereals of wheat, barley and rye which are non toxic to individuals with coeliac disease but which retain the nutritional and baking qualities of the original cultivars. Research in inflammatory bowel disease involves studying the disease mechanisms including the role of bacteria in the development of ulcerative colitis and pouchitis, a condition that affects individuals who have had an ileoanal pouch fashioned after a total colectomy for ulcerative colitis.

Publications

Most relevant publications:
Please note: We are unable to provide re-prints

1. Moodie, S J, Norman, P J, King, A L, Fraser, J S, Curtis, D, Ellis, H J, Vaughan, R & Ciclitira, P J (2002). Analysis of candidate genes and chromosomes in coeliac disease: An association study of the KIR and LILR gene cluster. European Journal Immunogenetics, 29, 287-291
   
   
2. Louka, A, Moodie, S J, Karell, K , Bolognesi E, Ascher H ,Greco L , Momligliano P, Partanen J, Sollid, L, Ciclitira, P J & The European Genetics Cluster on Coeliac Disease (2003). A European Search for non-DQA1*05-DQB1*02 coeliac disease Loci on HLA-DR3 Haplotypes: Analysis of Transmission from Homozygous parents. Human immunology. 64 350-358.
   
   
3. Karell, K, Loukam, A S, Moodie, S J, Ascher, H, Clerget-Darpoux, F, Greco L, Ciclitira, P J, Sollid L M & Partanen, J. (2002) HLA types in coeliac disease patients not carrying the DQA1* 05-DQB1*02 (DQ2) Heterodimer: Results from the European Genetics Cluster in coeliac disease. Human Immunology 64 469-477.
   
   
4. Moodie, S J , Norman, P, J, King, A L, Fraser, J S , Curtis, D, Ellis, H J, Vaughan & Ciclitira, P J (2002). Analysis of candidate genes on chromosome 11q in coeliac disease: An association study of the KIR and LILR gene cluster. European Journal of Immunogenetics 29 287-291.
   
   
5. H J Ellis, E L Pollock, W Engel, J S Fraser, S Rosen-Bronson, H Wieser, P J Ciclitira Investigation of the putative immunodominant T cell epitopes in coeliac disease (2003) Gut 52 212-217.
   
   
6. Fraser J S, Enoel W, Ellis H J, Moodie S J, Pollock E L, Wieser H, Ciclitira P J [2003]: Coeliac disease In-vivo toxicity of the putative immunodominant epitope. Gut 52, 1698-1702
   
   
7. King A L, Moodie S J, Fraser j S, Curtis D, Reid E, Deerlone A M, Ellis h J, Ciclitira p J [2003]: Investigation of the proposed causal variants in the CTL-4A gene, 124, European Journal of Immunogenetics [In press]
   
   
8. Babron M C, Nilsson S, Adamovic S, Naluai A T, Wahlstrom J, Ascher H, Ciclitira P J, Sollid M, Partanen J, Greco L, Clerget-Darpoux C D: (2003) Meta and Pooled analysis of European coeliac data, Journal of Human Genetics 11, 828-834
   
   
9. Holopainen P, Naluai A T, Moodie S, Percopo S, Coto I, Clot F, Ascher H, Ciclitira P J, Greco L, Clerget-Darpoux F, Partanen J (2004): Candidate gene region 2q33 in European families with coeliac disease Tissue Antigens (In press)
   
   
10. Bell, A, Nicholls R J, Forbes A, Ellis H J, Ciclitira P J (2004) Human lymphocyte stimulation with pouchitis flora is greater than with healthy flora but is suppressed by metronidazole ; Gut (In press)